Mus musculus Gene: Dusp12
InnateDB Gene IDBG-203854.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dusp12
Gene Name dual specificity phosphatase 12
Synonyms 1190004O14Rik; AA027408; AW049275; ESTM36; LMW-DSP4; mVH1; T-DSP4; VH1
Species Mus musculus
Ensembl Gene ENSMUSG00000026659
Encoded Proteins
dual specificity phosphatase 12
dual specificity phosphatase 12
dual specificity phosphatase 12
dual specificity phosphatase 12
dual specificity phosphatase 12
dual specificity phosphatase 12
dual specificity phosphatase 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000081721:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:170873498-170885540
Strand Reverse strand
Band H3
ENSMUST00000046476 ENSMUSP00000044320
ENSMUST00000027970 ENSMUSP00000027970
ENSMUST00000170420 ENSMUSP00000129515
ENSMUST00000171447 ENSMUSP00000130683
ENSMUST00000163252 ENSMUSP00000126676
ENSMUST00000166393 ENSMUSP00000130507
ENSMUST00000172042 ENSMUSP00000129530
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0019900 kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0033133 positive regulation of glucokinase activity
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
UniProt Splice Variant
Entrez Gene 80915
RefSeq NM_023173 XM_006497042
MGI ID MGI:1890614
MGI Symbol Dusp12
EMBL AC113490 CH466746
GenPept EDL03060 EDL03063
RNA Seq Atlas 80915