Version 5.4
Homo sapiens Gene: FGD5
Summary
InnateDB Gene IDBG-20412.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGD5
Gene Name FYVE, RhoGEF and PH domain containing 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154783
Encoded Proteins
IDBP-20414
FYVE, RhoGEF and PH domain containing 5
IDBP-365665
FYVE, RhoGEF and PH domain containing 5
IDBP-585887
FYVE, RhoGEF and PH domain containing 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:14818962-14934565
Strand Forward strand
Band p25.1
Transcripts
ENST00000285046 ENSP00000285046
ENST00000457774 ENSP00000394827
ENST00000468662
ENST00000476851
ENST00000487605
ENST00000543601 ENSP00000445949
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0031267 small GTPase binding
GO:0046872 metal ion binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0008360 regulation of cell shape
GO:0030036 actin cytoskeleton organization
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0043088 regulation of Cdc42 GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0046847 filopodium assembly
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0030027 lamellipodium
GO:0032587 ruffle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034037
View Gene Order
ENSBTAG00000006789
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.412406
RefSeq NM_152536 XM_005264900 XM_005264901
HUGO
OMIM
CCDS CCDS46767
HPRD 13322
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca