Version 5.4
Homo sapiens Gene: GGA2
Summary
InnateDB Gene IDBG-20428.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGA2
Gene Name golgi-associated, gamma adaptin ear containing, ARF binding protein 2
Synonyms VEAR
Species Homo sapiens
Ensembl Gene ENSG00000103365
Encoded Proteins
IDBP-20430
golgi-associated, gamma adaptin ear containing, ARF binding protein 2
IDBP-751156
IDBP-745042
IDBP-748842
IDBP-749570
IDBP-747132
IDBP-751402
IDBP-750376
IDBP-747060
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:23463542-23521995
Strand Reverse strand
Band p12.2
Transcripts
ENST00000309859 ENSP00000311962
ENST00000570111 ENSP00000454469
ENST00000567201
ENST00000566547
ENST00000562117 ENSP00000459414
ENST00000567339
ENST00000563047 ENSP00000455293
ENST00000566651
ENST00000569300 ENSP00000455331
ENST00000562944 ENSP00000459560
ENST00000568799
ENST00000568922
ENST00000563494 ENSP00000456247
ENST00000567468 ENSP00000454455
ENST00000566685
ENST00000569189 ENSP00000460975
ENST00000569182
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 51 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030306 ADP-ribosylation factor binding
Biological Process
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005622 intracellular
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0010008 endosome membrane
GO:0030131 clathrin adaptor complex
GO:0030136 clathrin-coated vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030872
View Gene Order
ENSBTAG00000002352
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.460336 Hs.619253 Hs.657076 Hs.705894
RefSeq NM_015044
HUGO
OMIM
CCDS CCDS10611
HPRD 09347
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca