Version 5.4
Mus musculus Gene: Ebf4
Summary
InnateDB Gene IDBG-206321.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ebf4
Gene Name early B cell factor 4
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000053552
Encoded Proteins
IDBP-260587
early B-cell factor 4
IDBP-260589
early B-cell factor 4
IDBP-260591
early B-cell factor 4
IDBP-627813
early B-cell factor 4
IDBP-627814
early B-cell factor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088881:
EBF4 belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors, members of which play important roles in neural development and B-cell maturation (Wang et al., 2002 [PubMed 12139918]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:130295169-130370481
Strand Forward strand
Band F1
Transcripts
ENSMUST00000110288 ENSMUSP00000105917
ENSMUST00000110287 ENSMUSP00000105916
ENSMUST00000110286 ENSMUSP00000105915
ENSMUST00000134728
ENSMUST00000126740 ENSMUSP00000133528
ENSMUST00000140169 ENSMUSP00000134520
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSG00000088881
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000037757
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q8K4J2
TrEMBL A2BI80 A2BI84 B2RQX3 B7ZNC0
UniProt Splice Variant
Entrez Gene 228598
UniGene Mm.32582 Mm.483929
RefSeq NM_001110513 XM_006499279 XM_006499280 XM_006499281 XM_006499283 XM_006499284 XM_006499285
OMIM
CCDS CCDS50709
HPRD
IMGT
MGI ID MGI:2385972
MGI Symbol Ebf4
EMBL AF387630 AF387631 AF387632 AF387633 AF387634 BC138119 BC145155 BX890605 BX936285 CH466519
GenPept AAI38120 AAI45156 AAM97580 AAM97581 AAM97582 AAM97583 AAM97584 CAM15942 CAM20114 EDL28257
RNA Seq Atlas 228598

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca