Version 5.4
Homo sapiens Gene: SNX18
Summary
InnateDB Gene IDBG-20654.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNX18
Gene Name sorting nexin 18
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000178996
Encoded Proteins
IDBP-20656
sorting nexin 18
IDBP-20658
sorting nexin 18
IDBP-35227
sorting nexin 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:54517759-54546585
Strand Forward strand
Band q11.2
Transcripts
ENST00000381410 ENSP00000370817
ENST00000326277 ENSP00000317332
ENST00000343017 ENSP00000342276
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0007067 mitotic nuclear division
GO:0015031 protein transport
GO:0016197 endosomal transport
GO:0036089 cleavage furrow formation
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005768 endosome
GO:0010008 endosome membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030136 clathrin-coated vesicle
GO:0030426 growth cone
GO:0030659 cytoplasmic vesicle membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042364
View Gene Order
ENSBTAG00000027924
Not yet available
Cross-References
SwissProt Q96RF0
TrEMBL
UniProt Splice Variant
Entrez Gene 112574
UniGene Hs.432755 Hs.606166
RefSeq NM_001102575 NM_001145427 NM_052870
HUGO HGNC:19245
OMIM
CCDS CCDS43317 CCDS3962 CCDS54851
HPRD 15407
IMGT
EMBL AC091888 AF395536 AK304195 BC060791 BC067860 BC117218 BC117220 CH471123
GenPept AAH60791 AAH67860 AAI17219 AAI17221 AAK82415 BAG65075 EAW54894
RNA Seq Atlas 112574

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca