InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ccr3

Summary

InnateDB Gene

IDBG-206550.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccr3

Gene Name

chemokine (C-C motif) receptor 3

Synonyms

CC-CKR3; CKR3; Cmkbr1l2; Cmkbr3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035448

Encoded Proteins

IDBP-206552

chemokine (C-C motif) receptor 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21660963

Epithelial Ccr3 is involved in the progression of LPS-induced lung inflammation by mediating the release of Il8.

InnateDB Annotation from Orthologs

Summary

PMID 21660963

[Homo sapiens] Epithelial CCR3 is involved in the progression of LPS-induced lung inflammation by mediating the release of IL8.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183625:
The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:124021971-124031689

Strand

Forward strand

Band

Transcripts

ENSMUST00000039171

ENSMUSP00000039107

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0070098	chemokine-mediated signaling pathway