InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rpl22

Summary

InnateDB Gene

IDBG-206668.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rpl22

Gene Name

ribosomal protein L22

Synonyms

2700038K18Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028936

Encoded Proteins

IDBP-206672

ribosomal protein L22

IDBP-537761

ribosomal protein L22

IDBP-788230

ribosomal protein L22

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116251:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:152325742-152334071

Strand

Forward strand

Band

Transcripts

ENSMUST00000103191	ENSMUSP00000099480
ENSMUST00000142735
ENSMUST00000139685	ENSMUSP00000118787
ENSMUST00000126519
ENSMUST00000127659
ENSMUST00000150485
ENSMUST00000156445
ENSMUST00000188151	ENSMUSP00000140276

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	72 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006412	translation
GO:0046632	alpha-beta T cell differentiation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0030529	ribonucleoprotein complex
GO:0070062	extracellular vesicular exosome