InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DYNC1H1

Summary

InnateDB Gene

IDBG-20700.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DYNC1H1

Gene Name

dynein, cytoplasmic 1, heavy chain 1

Synonyms

DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22; SMALED1

Species

Homo sapiens

Ensembl Gene

ENSG00000197102

Encoded Proteins

IDBP-20704

dynein, cytoplasmic 1, heavy chain 1

IDBP-601369

dynein, cytoplasmic 1, heavy chain 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:101964528-102050792

Strand

Forward strand

Band

q32.31

Transcripts

ENST00000360184	ENSP00000348965
ENST00000555204
ENST00000554854
ENST00000556791
ENST00000553423	ENSP00000450674
ENST00000555800
ENST00000556139
ENST00000556499
ENST00000555102
ENST00000556229
ENST00000555062

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 126 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	126 [view]
Protein-Protein	126 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0044822	poly(A) RNA binding
GO:0051959	dynein light intermediate chain binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0007018	microtubule-based movement
GO:0007052	mitotic spindle organization
GO:0008219	cell death
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0033962	cytoplasmic mRNA processing body assembly
GO:0034063	stress granule assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005868	cytoplasmic dynein complex
GO:0005874	microtubule
GO:0016020	membrane
GO:0030175	filopodium
GO:0030286	dynein complex
GO:0070062	extracellular vesicular exosome