Mus musculus Gene: Rad51c
Summary
InnateDB Gene IDBG-207290.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rad51c
Gene Name RAD51 homolog c (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000007646
Encoded Proteins
RAD51 homolog c (S. cerevisiae)
RAD51 homolog c (S. cerevisiae)
RAD51 homolog c (S. cerevisiae)
RAD51 homolog c (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108384:
This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:87376645-87404954
Strand Reverse strand
Band C
Transcripts
ENSMUST00000067692 ENSMUSP00000064079
ENSMUST00000007790 ENSMUSP00000007790
ENSMUST00000153073 ENSMUSP00000122811
ENSMUST00000129400 ENSMUSP00000121928
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000400 four-way junction DNA binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
GO:0008821 crossover junction endodeoxyribonuclease activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006200 ATP catabolic process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0007066 female meiosis sister chromatid cohesion
GO:0007131 reciprocal meiotic recombination
GO:0007141 male meiosis I
GO:0007283 spermatogenesis
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex
GO:0033065 Rad51C-XRCC3 complex
GO:0048471 perinuclear region of cytoplasm
GO:0048476 Holliday junction resolvase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Hemostasis pathway
Factors involved in megakaryocyte development and platelet production pathway
KEGG
Homologous recombination pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Cell Cycle pathway
Meiotic recombination pathway
Factors involved in megakaryocyte development and platelet production pathway
Meiosis pathway
Hemostasis pathway
KEGG
Homologous recombination pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F2Z433 F2Z4A1
UniProt Splice Variant
Entrez Gene 114714
UniGene Mm.37376
RefSeq NM_053269
OMIM
CCDS CCDS25212
HPRD
IMGT
MGI ID MGI:2150020
MGI Symbol Rad51c
EMBL AL596130 AL669902
GenPept
RNA Seq Atlas 114714