Homo sapiens Gene: NRTN
Summary
InnateDB Gene IDBG-20764.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRTN
Gene Name neurturin
Synonyms NTN;
Species Homo sapiens
Ensembl Gene ENSG00000171119
Encoded Proteins
neurturin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:5823802-5828324
Strand Forward strand
Band p13.3
Transcripts
ENST00000303212 ENSP00000302648
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0000165 MAPK cascade
GO:0001755 neural crest cell migration
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0021675 nerve development
GO:0031175 neuron projection development
Cellular Component
GO:0005576 extracellular region
GO:0030424 axon
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
NCAM signaling for neurite out-growth pathway
NCAM1 interactions pathway
Axon guidance pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q99748
TrEMBL
UniProt Splice Variant
Entrez Gene 4902
UniGene Hs.234775
RefSeq NM_004558
HUGO HGNC:8007
OMIM 602018
CCDS CCDS12151
HPRD 03604
IMGT
EMBL AL161995 BC137399 BC137400 CH471139 U78110
GenPept AAC50898 AAI37400 AAI37401 CAB82327 EAW69140
RNA Seq Atlas 4902