InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Srsf1

Summary

InnateDB Gene

IDBG-207877.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Srsf1

Gene Name

serine/arginine-rich splicing factor 1

Synonyms

1110054N12Rik; 5730507C05Rik; 6330415C05Rik; AI482334; Asf; AW491331; Sf2; Sfrs1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018379

Encoded Proteins

IDBP-620866

serine/arginine-rich splicing factor 1

IDBP-265646

serine/arginine-rich splicing factor 1

IDBP-537679

serine/arginine-rich splicing factor 1

IDBP-537203

serine/arginine-rich splicing factor 1

IDBP-620867

serine/arginine-rich splicing factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:88047373-88053755

Strand

Forward strand

Band

Transcripts

ENSMUST00000079866	ENSMUSP00000133517
ENSMUST00000107920	ENSMUSP00000103553
ENSMUST00000139129	ENSMUSP00000120595
ENSMUST00000134824	ENSMUSP00000114549
ENSMUST00000132983
ENSMUST00000171976
ENSMUST00000172186	ENSMUSP00000128190

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 127 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	22 [view]
Protein-DNA	17 [view]
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	127 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0050733	RS domain binding

Biological Process

GO:0000395	mRNA 5'-splice site recognition
GO:0001701	in utero embryonic development
GO:0008380	RNA splicing
GO:0051028	mRNA transport
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016607	nuclear speck
GO:0035145	exon-exon junction complex
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome