Mus musculus Gene: Dvl1
Summary
InnateDB Gene IDBG-207981.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dvl1
Gene Name dishevelled, dsh homolog 1 (Drosophila)
Synonyms Dvl; mKIAA4029;
Species Mus musculus
Ensembl Gene ENSMUSG00000029071
Encoded Proteins
dishevelled, dsh homolog 1 (Drosophila)
dishevelled, dsh homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107404:
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:155847402-155859303
Strand Forward strand
Band E2
Transcripts
ENSMUST00000030948 ENSMUSP00000030948
ENSMUST00000156997
ENSMUST00000133184
ENSMUST00000141539
ENSMUST00000143457
ENSMUST00000140529
ENSMUST00000129450
ENSMUST00000168552 ENSMUSP00000133137
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 12 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0001505 regulation of neurotransmitter levels
GO:0001932 regulation of protein phosphorylation
GO:0001933 negative regulation of protein phosphorylation
GO:0006366 transcription from RNA polymerase II promoter
GO:0006469 negative regulation of protein kinase activity
GO:0007269 neurotransmitter secretion
GO:0007275 multicellular organismal development
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007528 neuromuscular junction development
GO:0010976 positive regulation of neuron projection development
GO:0016055 Wnt signaling pathway
GO:0021915 neural tube development
GO:0022007 convergent extension involved in neural plate elongation
GO:0030177 positive regulation of Wnt signaling pathway
GO:0031122 cytoplasmic microtubule organization
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504 protein localization to nucleus
GO:0035176 social behavior
GO:0035372 protein localization to microtubule
GO:0035556 intracellular signal transduction
GO:0043113 receptor clustering
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048668 collateral sprouting
GO:0048675 axon extension
GO:0048813 dendrite morphogenesis
GO:0050808 synapse organization
GO:0060029 convergent extension involved in organogenesis
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060134 prepulse inhibition
GO:0071340 skeletal muscle acetylcholine-gated channel clustering
GO:0090103 cochlea morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005938 cell cortex
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016328 lateral plasma membrane
GO:0030136 clathrin-coated vesicle
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031410 cytoplasmic vesicle
GO:0043025 neuronal cell body
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Disease pathway
Signaling by Wnt pathway
Signaling by WNT in cancer pathway
degradation of DVL pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
TCF dependent signaling in response to WNT pathway
Signal Transduction pathway
WNT mediated activation of DVL pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
Wnt signaling pathway pathway
Notch signaling pathway pathway
Melanogenesis pathway
Pathways in cancer pathway
Basal cell carcinoma pathway
INOH
Wnt signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TGF_beta_Receptor pathway
Wnt pathway
REACTOME
PCP/CE pathway pathway
WNT mediated activation of DVL pathway
negative regulation of TCF-dependent signaling by DVL-interacting proteins pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
degradation of DVL pathway
Signal Transduction pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
Notch signaling pathway pathway
Melanogenesis pathway
Pathways in cancer pathway
Basal cell carcinoma pathway
INOH
Wnt signaling pathway pathway
PID BIOCARTA
Segmentation clock [Biocarta view]
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
Agrin in postsynaptic differentiation [Biocarta view]
Multi-step regulation of transcription by pitx2 [Biocarta view]
Wnt signaling pathway [Biocarta view]
PID NCI
Presenilin action in Notch and Wnt signaling
Cross-References
SwissProt P51141
TrEMBL Q3TRW4
UniProt Splice Variant
Entrez Gene 13542
UniGene Mm.3400
RefSeq NM_010091
OMIM
CCDS CCDS19045
HPRD
IMGT
MGI ID MGI:94941
MGI Symbol Dvl1
EMBL AK155349 AK162430 AL670236 BC138848 BC138849 CH466594 U10115 U28138
GenPept AAA74049 AAA82175 AAI38849 AAI38850 BAE33208 BAE36912 CAM18392 EDL15045
RNA Seq Atlas 13542