Version 5.4
Mus musculus Gene: Col1a1
Summary
InnateDB Gene IDBG-209263.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Col1a1
Gene Name collagen, type I, alpha 1
Synonyms Col1a-1; Cola-1; Cola1; Mov-13; Mov13
Species Mus musculus
Ensembl Gene ENSMUSG00000001506
Encoded Proteins
IDBP-209265
collagen, type I, alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108821:
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:94936224-94953042
Strand Forward strand
Band D
Transcripts
ENSMUST00000001547 ENSMUSP00000001547
ENSMUST00000139974
ENSMUST00000148593
ENSMUST00000148046
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 9 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0048407 platelet-derived growth factor binding
Biological Process
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001568 blood vessel development
GO:0001649 osteoblast differentiation
GO:0001957 intramembranous ossification
GO:0001958 endochondral ossification
GO:0007584 response to nutrient
GO:0007601 visual perception
GO:0007605 sensory perception of sound
GO:0009612 response to mechanical stimulus
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010812 negative regulation of cell-substrate adhesion
GO:0015031 protein transport
GO:0030199 collagen fibril organization
GO:0030335 positive regulation of cell migration
GO:0031667 response to nutrient levels
GO:0031960 response to corticosteroid
GO:0032355 response to estradiol
GO:0032964 collagen biosynthetic process
GO:0034504 protein localization to nucleus
GO:0034505 tooth mineralization
GO:0042060 wound healing
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043434 response to peptide hormone
GO:0043588 skin development
GO:0043589 skin morphogenesis
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0044691 tooth eruption
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048545 response to steroid hormone
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0051591 response to cAMP
GO:0055093 response to hyperoxia
GO:0060325 face morphogenesis
GO:0060346 bone trabecula formation
GO:0060351 cartilage development involved in endochondral bone morphogenesis
GO:0070208 protein heterotrimerization
GO:0071230 cellular response to amino acid stimulus
GO:0071260 cellular response to mechanical stimulus
GO:0071300 cellular response to retinoic acid
GO:0071306 cellular response to vitamin E
GO:0071356 cellular response to tumor necrosis factor
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902617 response to fluoride
GO:1902618 cellular response to fluoride
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005581 collagen trimer
GO:0005584 collagen type I
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0030141 secretory granule
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108821
View Gene Order
ENSBTAG00000013103
Not yet available
Pathways
NETPATH
REACTOME
REACT_199045
Collagen formation pathway
REACT_199046
Assembly of collagen fibrils and other multimeric structures pathway
REACT_196644
Syndecan interactions pathway
REACT_224553
Hemostasis pathway
REACT_198984
Collagen biosynthesis and modifying enzymes pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_196595
Anchoring fibril formation pathway
REACT_206066
Extracellular matrix organization pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_196573
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_196581
Scavenging by Class A Receptors pathway
REACT_225107
Platelet Adhesion to exposed collagen pathway
REACT_220092
GPVI-mediated activation cascade pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_196606
ECM proteoglycans pathway
REACT_196607
Non-integrin membrane-ECM interactions pathway
REACT_196515
Crosslinking of collagen fibrils pathway
REACT_199052
Degradation of the extracellular matrix pathway
REACT_199055
Collagen degradation pathway
KEGG
mmu04512
ECM-receptor interaction pathway
mmu04510
Focal adhesion pathway
mmu05146
Amoebiasis pathway
mmu04974
Protein digestion and absorption pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_1230
Platelet Adhesion to exposed collagen pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_150268
Anchoring fibril formation pathway
REACT_150206
Crosslinking of collagen fibrils pathway
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_150401
Collagen degradation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_163942
Syndecan interactions pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_163699
Scavenging by Class A Receptors pathway
REACT_163906
ECM proteoglycans pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_120729
Collagen formation pathway
REACT_604
Hemostasis pathway
REACT_206550
Collagen formation pathway
REACT_208597
Cell surface interactions at the vascular wall pathway
REACT_219927
Non-integrin membrane-ECM interactions pathway
REACT_215758
Collagen biosynthesis and modifying enzymes pathway
REACT_223425
Extracellular matrix organization pathway
REACT_222620
Collagen degradation pathway
REACT_212196
Hemostasis pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_201925
Degradation of the extracellular matrix pathway
REACT_226104
Assembly of collagen fibrils and other multimeric structures pathway
REACT_209041
Scavenging by Class A Receptors pathway
REACT_215983
Anchoring fibril formation pathway
REACT_219098
GPVI-mediated activation cascade pathway
REACT_213817
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_207047
Integrin cell surface interactions pathway
REACT_224259
Crosslinking of collagen fibrils pathway
REACT_220688
Platelet Adhesion to exposed collagen pathway
REACT_222217
ECM proteoglycans pathway
REACT_204848
Syndecan interactions pathway
KEGG
hsa04512
ECM-receptor interaction pathway
hsa04510
Focal adhesion pathway
hsa05146
Amoebiasis pathway
hsa04974
Protein digestion and absorption pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
lymphangiogenesis_pathway
VEGFR3 signaling in lymphatic endothelium
il4_2pathway
IL4-mediated signaling events
integrin3_pathway
Beta3 integrin cell surface interactions
Cross-References
SwissProt P11087
TrEMBL Q61022 Q64353 Q99LL6
UniProt Splice Variant
Entrez Gene 12842
UniGene Mm.277735 Mm.458212
RefSeq NM_007742
OMIM
CCDS CCDS25265
HPRD
IMGT
MGI ID MGI:88467
MGI Symbol Col1a1
EMBL AL606480 AL662790 BC003198 BC050014 BC059281 K01688 K03029 K03030 K03031 K03032 K03033 K03034 K03035 K03036 M14423 M17491 M24372 M60424 S67482 S67530 U08020 U38544 X06753 X15896 X54876 X57981
GenPept AAA37129 AAA37130 AAA37330 AAA37332 AAA37333 AAA37334 AAA80676 AAA88912 AAB29424 AAH03198 AAH50014 AAH59281 CAA29927 CAA33904 CAA38657 CAA41046 CAI23970 CAI25880
RNA Seq Atlas 12842

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca