Version 5.4
| Mus musculus Gene: Il21r | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-209298.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Il21r | ||||||||
| Gene Name | interleukin 21 receptor | ||||||||
| Synonyms | NILR | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000030745 | ||||||||
| Encoded Proteins |
interleukin 21 receptor
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103522:
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 7:125603429-125633570 | ||||||||
| Strand | Forward strand | ||||||||
| Band | F3 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG |
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG |
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9JHX3 | ||||||||
| TrEMBL | Q3TAI3 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 60504 | ||||||||
| UniGene | |||||||||
| RefSeq | NM_021887 XM_006508098 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS21823 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:1890475 | ||||||||
| MGI Symbol | Il21r | ||||||||
| EMBL | AB049137 AF254068 AF269134 AF279436 AF477982 AF477983 AF477984 AF477985 AF477986 AK171826 CH466531 | ||||||||
| GenPept | AAF86350 AAG23420 AAG29347 AAL82632 AAL82633 AAL82634 AAL82635 AAL82636 BAB13736 BAE42685 EDL17327 | ||||||||
| RNA Seq Atlas | 60504 | ||||||||