Mus musculus Gene: Tufm
Summary
InnateDB Gene IDBG-209544.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tufm
Gene Name Tu translation elongation factor, mitochondrial
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000073838
Encoded Proteins
Tu translation elongation factor, mitochondrial
Tu translation elongation factor, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Tufm inhibits RLR-induced IFN-I and promotes autophagy during viral infection. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] TUFM inhibits RLR-induced IFN-I and promotes autophagy during viral infection.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178952:
This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:126487355-126490730
Strand Forward strand
Band F3
Transcripts
ENSMUST00000098048 ENSMUSP00000095656
ENSMUST00000106392 ENSMUSP00000102000
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 87 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 87 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006414 translational elongation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Mitochondrial translation pathway
Organelle biogenesis and maintenance pathway
Mitochondrial translation elongation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation elongation pathway
Mitochondrial translation elongation pathway
Mitochondrial translation pathway
Organelle biogenesis and maintenance pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.197829
RefSeq NM_001163713 NM_172745
OMIM
CCDS CCDS21830 CCDS52398
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas