Version 5.4
Mus musculus Gene: Hsd3b7
Summary
InnateDB Gene IDBG-210381.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hsd3b7
Gene Name hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Synonyms AI195443; BB098564
Species Mus musculus
Ensembl Gene ENSMUSG00000042289
Encoded Proteins
IDBP-210383
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
IDBP-269113
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
IDBP-269115
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
IDBP-538792
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
IDBP-540282
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099377:
This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:127785608-127803802
Strand Forward strand
Band F3
Transcripts
ENSMUST00000046863 ENSMUSP00000036245
ENSMUST00000106272 ENSMUSP00000101879
ENSMUST00000106271 ENSMUSP00000101878
ENSMUST00000154987
ENSMUST00000136823
ENSMUST00000132702
ENSMUST00000144748
ENSMUST00000125188
ENSMUST00000155005
ENSMUST00000124631
ENSMUST00000136597
ENSMUST00000139068 ENSMUSP00000121246
ENSMUST00000138432 ENSMUSP00000114536
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0008831 dTDP-4-dehydrorhamnose reductase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0047016 cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity
GO:0050662 coenzyme binding
Biological Process
GO:0006694 steroid biosynthetic process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0044237 cellular metabolic process
GO:0045226 extracellular polysaccharide biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000099377
View Gene Order
ENSBTAG00000002346
Not yet available
Pathways
NETPATH
REACTOME
REACT_210229
Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_207530
Synthesis of bile acids and bile salts pathway
REACT_203193
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_226440
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
REACT_229469
Bile acid and bile salt metabolism pathway
KEGG
mmu00120
Primary bile acid biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11053
Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway
REACT_11041
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_11048
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
REACT_11054
Synthesis of bile acids and bile salts pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00120
Primary bile acid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3YU71
UniProt Splice Variant
Entrez Gene 101502
UniGene Mm.486340
RefSeq NM_001040684 NM_133943
OMIM
CCDS CCDS40145
HPRD
IMGT
MGI ID MGI:2141879
MGI Symbol Hsd3b7
EMBL AC149222
GenPept
RNA Seq Atlas 101502

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca