Version 5.4
Homo sapiens Gene: PPIL2
Summary
InnateDB Gene IDBG-2106.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPIL2
Gene Name peptidylprolyl isomerase (cyclophilin)-like 2
Synonyms CYC4; Cyp-60; CYP60; hCyP-60; UBOX7
Species Homo sapiens
Ensembl Gene ENSG00000100023
Encoded Proteins
IDBP-2108
peptidylprolyl isomerase (cyclophilin)-like 2
IDBP-232057
peptidylprolyl isomerase (cyclophilin)-like 2
IDBP-292705
peptidylprolyl isomerase (cyclophilin)-like 2
IDBP-365266
peptidylprolyl isomerase (cyclophilin)-like 2
IDBP-365269
peptidylprolyl isomerase (cyclophilin)-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:21652270-21700015
Strand Forward strand
Band q11.21
Transcripts
ENST00000335025 ENSP00000334553
ENST00000398831 ENSP00000381812
ENST00000406385 ENSP00000384299
ENST00000417788 ENSP00000406745
ENST00000458567 ENSP00000395181
ENST00000446951
ENST00000498589
ENST00000496819
ENST00000484439
ENST00000498109
ENST00000485930
ENST00000462188
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 13 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0034450 ubiquitin-ubiquitin ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0007596 blood coagulation
GO:0016567 protein ubiquitination
GO:0050900 leukocyte migration
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005796 Golgi lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022771
View Gene Order
ENSBTAG00000021121
Not yet available
Pathways
NETPATH
REACTOME
REACT_12560
Basigin interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.438587 Hs.533020
RefSeq NM_014337 NM_148175 NM_148176 XM_006724197
HUGO
OMIM
CCDS CCDS13793
HPRD 08472
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca