InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Smarce1

Summary

InnateDB Gene

IDBG-210926.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smarce1

Gene Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

Synonyms

2810417B20Rik; 5830412H02Rik; 9030408N19Rik; Baf27

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037935

Encoded Proteins

IDBP-210928

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 17669635

[Homo sapiens] SMARCE1 is a transcriptional modulator that is known to repress viral replication.

PMID 16135788

[Homo sapiens] SMARCE1 is associated with up-regulation of proapoptotic genes, including the tumour suppressor familial cylindromatosis (CYLD).

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073584:
The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:99209047-99231017

Strand

Reverse strand

Band

Transcripts

ENSMUST00000103133	ENSMUSP00000099422
ENSMUST00000156160
ENSMUST00000155062
ENSMUST00000135040
ENSMUST00000128707
ENSMUST00000128215

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008080	N-acetyltransferase activity
GO:0016922	ligand-dependent nuclear receptor binding
GO:0031492	nucleosomal DNA binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006337	nucleosome disassembly
GO:0006338	chromatin remodeling
GO:0007399	nervous system development
GO:0008152	metabolic process
GO:0043044	ATP-dependent chromatin remodeling
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0016514	SWI/SNF complex
GO:0017053	transcriptional repressor complex
GO:0043234	protein complex
GO:0071564	npBAF complex
GO:0071565	nBAF complex