InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ptpre

Summary

InnateDB Gene

IDBG-211354.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptpre

Gene Name

protein tyrosine phosphatase, receptor type, E

Synonyms

PTPe; PTPepsilon; RPTPepsilon

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041836

Encoded Proteins

IDBP-211356

protein tyrosine phosphatase, receptor type, E

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132334:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:135537824-135686294

Strand

Forward strand

Band

Transcripts

ENSMUST00000073961

ENSMUSP00000073616

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0016311	dephosphorylation
GO:0033003	regulation of mast cell activation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0046627	negative regulation of insulin receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0045111	intermediate filament cytoskeleton

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000132334

View Gene Order

ENSBTAG00000002435

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

il6_7pathway

IL6-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.401996 Mm.468164 Mm.945

RefSeq

NM_011212 XM_006507458 XM_006507459 XM_006507460 XM_006507461

OMIM

CCDS

CCDS21944

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas