Homo sapiens Gene: SNAI2
Summary
InnateDB Gene IDBG-21210.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNAI2
Gene Name snail homolog 2 (Drosophila)
Synonyms SLUG; SLUGH1; SNAIL2; WS2D;
Species Homo sapiens
Ensembl Gene ENSG00000019549
Encoded Proteins
snail homolog 2 (Drosophila)
snail homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:48917690-48921740
Strand Reverse strand
Band q11.21
Transcripts
ENST00000020945 ENSP00000020945
ENST00000396822 ENSP00000380034
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 22 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003682 chromatin binding
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001649 osteoblast differentiation
GO:0001837 epithelial to mesenchymal transition
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003273 cell migration involved in endocardial cushion formation
GO:0006366 transcription from RNA polymerase II promoter
GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007219 Notch signaling pathway
GO:0007605 sensory perception of sound
GO:0009314 response to radiation
GO:0010839 negative regulation of keratinocyte proliferation
GO:0010957 negative regulation of vitamin D biosynthetic process
GO:0014032 neural crest cell development
GO:0016477 cell migration
GO:0030335 positive regulation of cell migration
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032642 regulation of chemokine production
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0035066 positive regulation of histone acetylation
GO:0035414 negative regulation of catenin import into nucleus
GO:0035921 desmosome disassembly
GO:0043066 negative regulation of apoptotic process
GO:0043473 pigmentation
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045600 positive regulation of fat cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0050872 white fat cell differentiation
GO:0060021 palate development
GO:0060070 canonical Wnt signaling pathway
GO:0060429 epithelium development
GO:0060536 cartilage morphogenesis
GO:0060693 regulation of branching involved in salivary gland morphogenesis
GO:0070563 negative regulation of vitamin D receptor signaling pathway
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071479 cellular response to ionizing radiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1900387 negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000647 negative regulation of stem cell proliferation
GO:2000810 regulation of tight junction assembly
GO:2000811 negative regulation of anoikis
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Adherens junction pathway
INOH
PID BIOCARTA
Downregulated of mta-3 in er-negative breast tumors [Biocarta view]
PID NCI
Direct p53 effectors
Regulation of nuclear beta catenin signaling and target gene transcription
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt O43623
TrEMBL
UniProt Splice Variant
Entrez Gene 6591
UniGene Hs.360174
RefSeq NM_003068
HUGO HGNC:11094
OMIM 602150
CCDS CCDS6146
HPRD 03689
IMGT
EMBL AF042001 AF084243 AK223368 AK312661 BC014890 BC015895 CH471068
GenPept AAC34288 AAD55240 AAH14890 AAH15895 BAD97088 BAG35543 EAW86700
RNA Seq Atlas 6591