Version 5.4
Homo sapiens Gene: SNAI2
Summary
InnateDB Gene IDBG-21210.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNAI2
Gene Name snail homolog 2 (Drosophila)
Synonyms SLUG; SLUGH1; SNAIL2; WS2D
Species Homo sapiens
Ensembl Gene ENSG00000019549
Encoded Proteins
IDBP-21212
snail homolog 2 (Drosophila)
IDBP-236696
snail homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:48917690-48921740
Strand Reverse strand
Band q11.21
Transcripts
ENST00000020945 ENSP00000020945
ENST00000396822 ENSP00000380034
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 22 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003682 chromatin binding
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001649 osteoblast differentiation
GO:0001837 epithelial to mesenchymal transition
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003273 cell migration involved in endocardial cushion formation
GO:0006366 transcription from RNA polymerase II promoter
GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007219 Notch signaling pathway
GO:0007605 sensory perception of sound
GO:0009314 response to radiation
GO:0010839 negative regulation of keratinocyte proliferation
GO:0010957 negative regulation of vitamin D biosynthetic process
GO:0014032 neural crest cell development
GO:0016477 cell migration
GO:0030335 positive regulation of cell migration
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032642 regulation of chemokine production
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0035066 positive regulation of histone acetylation
GO:0035414 negative regulation of catenin import into nucleus
GO:0035921 desmosome disassembly
GO:0043066 negative regulation of apoptotic process
GO:0043473 pigmentation
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045600 positive regulation of fat cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0050872 white fat cell differentiation
GO:0060021 palate development
GO:0060070 canonical Wnt signaling pathway
GO:0060429 epithelium development
GO:0060536 cartilage morphogenesis
GO:0060693 regulation of branching involved in salivary gland morphogenesis
GO:0070563 negative regulation of vitamin D receptor signaling pathway
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071479 cellular response to ionizing radiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1900387 negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000647 negative regulation of stem cell proliferation
GO:2000810 regulation of tight junction assembly
GO:2000811 negative regulation of anoikis
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022676
View Gene Order
ENSBTAG00000013227
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04520
Adherens junction pathway
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.360174
RefSeq NM_003068
HUGO
OMIM
CCDS CCDS6146
HPRD 03689
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca