Version 5.4
Mus musculus Gene: Shank2
Summary
InnateDB Gene IDBG-212862.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Shank2
Gene Name SH3/ankyrin domain gene 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000037541
Encoded Proteins
IDBP-212866
SH3/ankyrin domain gene 2
IDBP-269887
SH3/ankyrin domain gene 2
IDBP-269889
SH3/ankyrin domain gene 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162105:
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:144001928-144424494
Strand Forward strand
Band F5
Transcripts
ENSMUST00000097929 ENSMUSP00000095542
ENSMUST00000105902 ENSMUSP00000101522
ENSMUST00000105900 ENSMUSP00000101520
ENSMUST00000146006
ENSMUST00000136979
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0035255 ionotropic glutamate receptor binding
Biological Process
GO:0007416 synapse assembly
GO:0007612 learning
GO:0007613 memory
GO:0030534 adult behavior
GO:0035176 social behavior
GO:0035640 exploration behavior
GO:0060291 long-term synaptic potentiation
GO:0060292 long term synaptic depression
GO:0071625 vocalization behavior
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0005883 neurofilament
GO:0005886 plasma membrane
GO:0008328 ionotropic glutamate receptor complex
GO:0014069 postsynaptic density
GO:0016324 apical plasma membrane
GO:0030054 cell junction
GO:0030426 growth cone
GO:0031526 brush border membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0045211 postsynaptic membrane
GO:0060170 ciliary membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000162105
View Gene Order
ENSBTAG00000003171
Not yet available
Cross-References
SwissProt Q80Z38
TrEMBL
UniProt Splice Variant
Entrez Gene 210274
UniGene Mm.404448 Mm.483624
RefSeq NM_001081370 NM_001113373 XM_006508519 XM_006508520 XM_006508521 XM_006508522 XM_006508523 XM_006508524 XM_006508525 XM_006508530 XM_006508531 XM_006508532 XM_006508533 XM_006508534 XM_006508535 XM_006508536
OMIM
CCDS CCDS40201
HPRD
IMGT
MGI ID MGI:2671987
MGI Symbol Shank2
EMBL AB099695 AC124520 AC127546 AC140268 AC152166 AK139360 AK220363 BC167171
GenPept AAI67171 BAC58120 BAD90424 BAE23976
RNA Seq Atlas 210274

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca