Mus musculus Gene: Cse1l
Summary
InnateDB Gene IDBG-212948.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cse1l
Gene Name chromosome segregation 1-like (S. cerevisiae)
Synonyms 2610100P18Rik; AA407533; Capts; Cas; Xpo2
Species Mus musculus
Ensembl Gene ENSMUSG00000002718
Encoded Proteins
chromosome segregation 1-like (S. cerevisiae)
chromosome segregation 1-like (S. cerevisiae)
chromosome segregation 1-like (S. cerevisiae)
chromosome segregation 1-like (S. cerevisiae)
chromosome segregation 1-like (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124207:
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:166906040-166946389
Strand Forward strand
Band H3
Transcripts
ENSMUST00000002790 ENSMUSP00000002790
ENSMUST00000132402
ENSMUST00000135139
ENSMUST00000145819
ENSMUST00000129061
ENSMUST00000171410
ENSMUST00000169290 ENSMUSP00000128376
ENSMUST00000168599 ENSMUSP00000129983
ENSMUST00000163437 ENSMUSP00000126757
ENSMUST00000166871
ENSMUST00000164974 ENSMUSP00000128515
ENSMUST00000163917
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 57 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008536 Ran GTPase binding
Biological Process
GO:0006886 intracellular protein transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Direct p53 effectors
p53 pathway
Cross-References
SwissProt
TrEMBL E9Q1T9 Q9CSW8
UniProt Splice Variant
Entrez Gene 110750
UniGene Mm.22417 Mm.407673
RefSeq NM_023565
OMIM
CCDS CCDS17092
HPRD
IMGT
MGI ID MGI:1339951
MGI Symbol Cse1l
EMBL AK011791 AL591711 AL591911
GenPept BAB27843
RNA Seq Atlas 110750