Homo sapiens Gene: NUP88
Summary
InnateDB Gene IDBG-21334.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUP88
Gene Name nucleoporin 88kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000108559
Encoded Proteins
nucleoporin 88kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:5360963-5420160
Strand Reverse strand
Band p13.2
Transcripts
ENST00000225696 ENSP00000225696
ENST00000573169
ENST00000575976
ENST00000574867
ENST00000574087
ENST00000573584 ENSP00000458954
ENST00000572809 ENSP00000459370
ENST00000572019
ENST00000576862
ENST00000570937
ENST00000576708 ENSP00000461334
ENST00000572290 ENSP00000459979
ENST00000574855
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 27 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
Biological Process
GO:0000278 mitotic cell cycle
GO:0005975 carbohydrate metabolic process
GO:0007077 mitotic nuclear envelope disassembly
GO:0008645 hexose transport
GO:0010827 regulation of glucose transport
GO:0015031 protein transport
GO:0015758 glucose transport
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0044281 small molecule metabolic process
GO:0051028 mRNA transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Influenza Infection pathway
Interactions of Vpr with host cellular proteins pathway
Vpr-mediated nuclear import of PICs pathway
Myoclonic epilepsy of Lafora pathway
Antiviral mechanism by IFN-stimulated genes pathway
Glucose transport pathway
Hexose transport pathway
Cytokine Signaling in Immune system pathway
Metabolism of carbohydrates pathway
Late Phase of HIV Life Cycle pathway
Viral Messenger RNA Synthesis pathway
Transcriptional regulation by small RNAs pathway
Nuclear Pore Complex (NPC) Disassembly pathway
Influenza Viral RNA Transcription and Replication pathway
Interferon Signaling pathway
Cell Cycle pathway
Immune System pathway
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
M Phase pathway
HIV Life Cycle pathway
Mitotic Prophase pathway
Rev-mediated nuclear export of HIV RNA pathway
Cell Cycle, Mitotic pathway
HIV Infection pathway
ISG15 antiviral mechanism pathway
Influenza Life Cycle pathway
Nuclear import of Rev protein pathway
Metabolism pathway
Host Interactions of HIV factors pathway
SLC-mediated transmembrane transport pathway
Interactions of Rev with host cellular proteins pathway
Gene Expression pathway
Nuclear Envelope Breakdown pathway
Disease pathway
Glycogen storage diseases pathway
Regulatory RNA pathways pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q99567
TrEMBL B4DP20 I3L245 I3L2W3
UniProt Splice Variant
Entrez Gene 4927
UniGene Hs.584784 Hs.732144 Hs.743433
RefSeq NM_002532 XM_005256659
HUGO HGNC:8067
OMIM 602552
CCDS CCDS11070
HPRD
IMGT
EMBL AC004148 AC015727 AK298158 BC000335 CH471108 Y08612
GenPept AAH00335 BAG60432 CAA69904 EAW90340 EAW90342
RNA Seq Atlas 4927