Version 5.4
Mus musculus Gene: Ddx5
Summary
InnateDB Gene IDBG-213550.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ddx5
Gene Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
Synonyms 2600009A06Rik; G17P1; Hlr1; HUMP68; p68
Species Mus musculus
Ensembl Gene ENSMUSG00000020719
Encoded Proteins
IDBP-213552
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
IDBP-789831
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
IDBP-789832
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
IDBP-533892
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
IDBP-531698
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108654:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified. [provided by RefSeq, Jul 2008]
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:106780355-106789185
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000021062 ENSMUSP00000021062
ENSMUST00000106779
ENSMUST00000106778
ENSMUST00000133426 ENSMUSP00000138237
ENSMUST00000127481 ENSMUSP00000138184
ENSMUST00000130172
ENSMUST00000151741
ENSMUST00000129585 ENSMUSP00000116859
ENSMUST00000123339 ENSMUSP00000121733
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 147 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 147 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0003724 RNA helicase activity
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0019899 enzyme binding
GO:0030331 estrogen receptor binding
GO:0036002 pre-mRNA binding
GO:0044822 poly(A) RNA binding
GO:0048306 calcium-dependent protein binding
GO:0050681 androgen receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0001701 in utero embryonic development
GO:0006200 ATP catabolic process
GO:0007623 circadian rhythm
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045069 regulation of viral genome replication
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060765 regulation of androgen receptor signaling pathway
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0070062 extracellular vesicular exosome
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108654
View Gene Order
ENSBTAG00000018423
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03040
Spliceosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL S4R1E3
UniProt Splice Variant
Entrez Gene 13207
UniGene
RefSeq NM_007840 XM_006532135 XM_006532136 XM_006532137
OMIM
CCDS CCDS25562
HPRD
IMGT
MGI ID MGI:105037
MGI Symbol Ddx5
EMBL AL603664
GenPept
RNA Seq Atlas 13207

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca