Homo sapiens Gene: PSPN
Summary
InnateDB Gene IDBG-21373.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSPN
Gene Name persephin
Synonyms PSP;
Species Homo sapiens
Ensembl Gene ENSG00000125650
Encoded Proteins
persephin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a neurotrophic factor, belonging to the GDNF family. Neurotrophic factors are important for the proper development and maintenance of the nervous system. These factors promote neuronal survival and can prevent the neuronal degeneration associated with injury, toxin exposure, or neurodegenerative disease. The encoded protein has amino acid similarity to its other family members, glial cell line-derived neurotrophic factor and neurturin. This gene product promotes the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:6375148-6379058
Strand Reverse strand
Band p13.3
Transcripts
ENST00000245810 ENSP00000245810
ENST00000597721 ENSP00000469884
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007417 central nervous system development
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
NCAM signaling for neurite out-growth pathway
NCAM1 interactions pathway
Axon guidance pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL M0QYK2
UniProt Splice Variant
Entrez Gene 5623
UniGene Hs.634471 Hs.711684 Hs.742105
RefSeq NM_004158
HUGO HGNC:9579
OMIM 602921
CCDS CCDS12164
HPRD 04230
IMGT
EMBL AC011491
GenPept
RNA Seq Atlas 5623