InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lama5

Summary

InnateDB Gene

IDBG-213777.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lama5

Gene Name

laminin, alpha 5

Synonyms

[a]5; AA408760; AA408762; AI853660; laminin-511; mKIAA0533

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015647

Encoded Proteins

IDBP-213781

laminin, alpha 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130702:
Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:180176373-180225859

Strand

Reverse strand

Band

Transcripts

ENSMUST00000015791	ENSMUSP00000015791
ENSMUST00000130796
ENSMUST00000149812
ENSMUST00000123906

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005178	integrin binding
GO:0005515	protein binding

Biological Process

GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001738	morphogenesis of a polarized epithelium
GO:0001755	neural crest cell migration
GO:0001942	hair follicle development
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007517	muscle organ development
GO:0009887	organ morphogenesis
GO:0016331	morphogenesis of embryonic epithelium
GO:0016477	cell migration
GO:0030155	regulation of cell adhesion
GO:0030324	lung development
GO:0030334	regulation of cell migration
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042127	regulation of cell proliferation
GO:0042384	cilium assembly
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045995	regulation of embryonic development
GO:0048754	branching morphogenesis of an epithelial tube
GO:0060445	branching involved in salivary gland morphogenesis
GO:0090002	establishment of protein localization to plasma membrane

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005605	basal lamina
GO:0005606	laminin-1 complex
GO:0005610	laminin-5 complex
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0031012	extracellular matrix
GO:0043259	laminin-10 complex
GO:0070062	extracellular vesicular exosome