Version 5.4
Mus musculus Gene: Kcnq2
Summary
InnateDB Gene IDBG-213954.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnq2
Gene Name potassium voltage-gated channel, subfamily Q, member 2
Synonyms HNSPC; KQT2; Nmf134
Species Mus musculus
Ensembl Gene ENSMUSG00000016346
Encoded Proteins
IDBP-213956
potassium voltage-gated channel, subfamily Q, member 2
IDBP-213958
potassium voltage-gated channel, subfamily Q, member 2
IDBP-213960
potassium voltage-gated channel, subfamily Q, member 2
IDBP-213962
potassium voltage-gated channel, subfamily Q, member 2
IDBP-213964
potassium voltage-gated channel, subfamily Q, member 2
IDBP-213966
potassium voltage-gated channel, subfamily Q, member 2
IDBP-213968
potassium voltage-gated channel, subfamily Q, member 2
IDBP-213970
potassium voltage-gated channel, subfamily Q, member 2
IDBP-535762
potassium voltage-gated channel, subfamily Q, member 2
IDBP-539537
potassium voltage-gated channel, subfamily Q, member 2
IDBP-626628
potassium voltage-gated channel, subfamily Q, member 2
IDBP-626630
potassium voltage-gated channel, subfamily Q, member 2
IDBP-626635
potassium voltage-gated channel, subfamily Q, member 2
IDBP-626636
potassium voltage-gated channel, subfamily Q, member 2
IDBP-626637
potassium voltage-gated channel, subfamily Q, member 2
IDBP-626638
potassium voltage-gated channel, subfamily Q, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075043:
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:181075579-181135291
Strand Reverse strand
Band H4
Transcripts
ENSMUST00000016491 ENSMUSP00000016491
ENSMUST00000049792 ENSMUSP00000052453
ENSMUST00000103051 ENSMUSP00000099340
ENSMUST00000103050 ENSMUSP00000099339
ENSMUST00000081528 ENSMUSP00000080243
ENSMUST00000103049 ENSMUSP00000099338
ENSMUST00000103048 ENSMUSP00000099337
ENSMUST00000103047 ENSMUSP00000099336
ENSMUST00000149964 ENSMUSP00000122915
ENSMUST00000129695 ENSMUSP00000123488
ENSMUST00000145861
ENSMUST00000129073 ENSMUSP00000127061
ENSMUST00000152099
ENSMUST00000144592 ENSMUSP00000133237
ENSMUST00000139458 ENSMUSP00000130633
ENSMUST00000140789
ENSMUST00000154164 ENSMUSP00000131544
ENSMUST00000123336 ENSMUSP00000130700
ENSMUST00000129361 ENSMUSP00000131756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005267 potassium channel activity
GO:0030506 ankyrin binding
Biological Process
GO:0006811 ion transport
GO:0019226 transmission of nerve impulse
GO:0034765 regulation of ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0033268 node of Ranvier
GO:0043194 axon initial segment
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000075043
View Gene Order
ENSBTAG00000003030
Not yet available
Pathways
NETPATH
REACTOME
REACT_202800
Potassium Channels pathway
REACT_244931
Interaction between L1 and Ankyrins pathway
REACT_261444
Axon guidance pathway
REACT_219680
L1CAM interactions pathway
REACT_259290
Neuronal System pathway
REACT_188576
Developmental Biology pathway
REACT_199077
Voltage gated Potassium channels pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75770
Voltage gated Potassium channels pathway
REACT_22266
Interaction between L1 and Ankyrins pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_13685
Neuronal System pathway
REACT_18266
Axon guidance pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.40615 Mm.409325 Mm.411074 Mm.411110 Mm.445614
RefSeq NM_001003824 NM_001003825 NM_001006668 NM_001006669 NM_001006674 NM_001006675 NM_001006676 NM_001006677 NM_001006678 NM_001006679 NM_001006680 NM_010611
OMIM
CCDS CCDS17193 CCDS17194 CCDS17195 CCDS17196 CCDS17197 CCDS17198 CCDS17199 CCDS17200 CCDS50845 CCDS50846 CCDS50847 CCDS50848
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca