Homo sapiens Gene: MAPK1
Summary
InnateDB Gene IDBG-2147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPK1
Gene Name mitogen-activated protein kinase 1
Synonyms ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2;
Species Homo sapiens
Ensembl Gene ENSG00000100030
Encoded Proteins
mitogen-activated protein kinase 1
mitogen-activated protein kinase 1
mitogen-activated protein kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
MAPK1 (ERK) and MAPK14 (p38) control the dynamic balance regulating neutrophil migration.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Mapk1 (ERK) and Mapk14 (p38) control the dynamic balance regulating neutrophil migration. (Demonstrated in human)
[Mus musculus] Ptpn11 phosphatase function positively regulates Clec7a- and Itgam-stimulated reactive oxygen species production in macrophages by dephosphorylating and thus mitigating the inhibitory function of Sirpa and by promoting Mapk1/Mapk3 activation.
[Mus musculus] Prostaglandin E2 transactivates Csf1r and synergizes with its signalling at Mapk1/Mapk3 level in promoting macrophage migration.
Entrez Gene
Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:21754500-21867680
Strand Reverse strand
Band q11.22
Transcripts
ENST00000215832 ENSP00000215832
ENST00000398822 ENSP00000381803
ENST00000491588
ENST00000544786 ENSP00000440842
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 359 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Experimentally validated
Total 359 [view]
Protein-Protein 356 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001784 phosphotyrosine binding
GO:0003677 DNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0000189 MAPK import into nucleus
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006935 chemotaxis
GO:0006950 response to stress
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007268 synaptic transmission
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009636 response to toxic substance
GO:0009887 organ morphogenesis
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0016032 viral process
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019233 sensory perception of pain
GO:0019858 cytosine metabolic process
GO:0030168 platelet activation
GO:0030335 positive regulation of cell migration
GO:0031647 regulation of protein stability
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032872 regulation of stress-activated MAPK cascade
GO:0033598 mammary gland epithelial cell proliferation
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035556 intracellular signal transduction
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0038127 ERBB signaling pathway
GO:0043330 response to exogenous dsRNA
GO:0043627 response to estrogen
GO:0045087 innate immune response (InnateDB)
GO:0045596 negative regulation of cell differentiation
GO:0045727 positive regulation of translation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0051493 regulation of cytoskeleton organization
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060716 labyrinthine layer blood vessel development
GO:0070371 ERK1 and ERK2 cascade
GO:0070849 response to epidermal growth factor
GO:0071310 cellular response to organic substance
GO:0072584 caveolin-mediated endocytosis
GO:0090170 regulation of Golgi inheritance
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:2000641 regulation of early endosome to late endosome transport
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005901 caveola
GO:0005925 focal adhesion
GO:0015630 microtubule cytoskeleton
GO:0030424 axon
GO:0031143 pseudopodium
GO:0032839 dendrite cytoplasm
GO:0043204 perikaryon
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
GO:0072686 mitotic spindle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
Alpha6Beta4Integrin pathway
Notch pathway
EGFR1 pathway
ID pathway
KitReceptor pathway
TGF_beta_Receptor pathway
Wnt pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL1 pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
IL-7 pathway
IL9 pathway
RANKL pathway
Leptin pathway
TSH pathway
TSLP pathway
FSH pathway
TWEAK pathway
Prolactin pathway
IL11 pathway
Oncostatin_M pathway
REACTOME
RSK activation pathway
Signaling by FGFR in disease pathway
SHC-related events pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Cellular responses to stress pathway
MyD88 dependent cascade initiated on endosome pathway
Thrombin signalling through proteinase activated receptors (PARs) pathway
Developmental Biology pathway
Oncogene Induced Senescence pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signalling to p38 via RIT and RIN pathway
FRS2-mediated cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SOS-mediated signalling pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Regulation of HSF1-mediated heat shock response pathway
ERK2 activation pathway
SHC1 events in ERBB4 signaling pathway
DAP12 signaling pathway
NCAM signaling for neurite out-growth pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
GRB2 events in ERBB2 signaling pathway
Neuronal System pathway
MyD88 cascade initiated on plasma membrane pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
PLC beta mediated events pathway
ERKs are inactivated pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
SHC-related events triggered by IGF1R pathway
Activation of the AP-1 family of transcription factors pathway
Platelet activation, signaling and aggregation pathway
Signaling by SCF-KIT pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Frs2-mediated activation pathway
phospho-PLA2 pathway pathway
Toll-Like Receptors Cascades pathway
Axon guidance pathway
RAF/MAP kinase cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Opioid Signalling pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
Post NMDA receptor activation events pathway
IRS-mediated signalling pathway
G-protein mediated events pathway
Cell Cycle pathway
Recycling pathway of L1 pathway
SHC1 events in EGFR signaling pathway
Golgi Cisternae Pericentriolar Stack Reorganization pathway
SHC-mediated signalling pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Downstream signal transduction pathway
GRB2 events in EGFR signaling pathway
VEGFR2 mediated cell proliferation pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
CREB phosphorylation through the activation of Ras pathway
Insulin receptor signalling cascade pathway
M Phase pathway
Cellular Senescence pathway
Interleukin-2 signaling pathway
Growth hormone receptor signaling pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
Cellular response to heat stress pathway
IRS-related events pathway
Mitotic Prophase pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Transmission across Chemical Synapses pathway
L1CAM interactions pathway
SHC1 events in ERBB2 signaling pathway
Signal transduction by L1 pathway
IGF1R signaling cascade pathway
ARMS-mediated activation pathway
Cell Cycle, Mitotic pathway
Signal attenuation pathway
Prolonged ERK activation events pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
Nuclear Events (kinase and transcription factor activation) pathway
Signaling by FGFR pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Signalling to RAS pathway
Signaling by PDGF pathway
Advanced glycosylation endproduct receptor signaling pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Negative regulation of FGFR signaling pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
ERK activation pathway
Oxidative Stress Induced Senescence pathway
ERK/MAPK targets pathway
Ca-dependent events pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Disease pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Signaling by Leptin pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
DAP12 interactions pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Oocyte meiosis pathway
mTOR signaling pathway pathway
Vascular smooth muscle contraction pathway
Dorso-ventral axis formation pathway
TGF-beta signaling pathway pathway
Axon guidance pathway
VEGF signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Adherens junction pathway
Gap junction pathway
Toll-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Long-term depression pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Melanogenesis pathway
Type II diabetes mellitus pathway
Aldosterone-regulated sodium reabsorption pathway
Alzheimer's disease pathway
Prion diseases pathway
Shigellosis pathway
Leishmaniasis pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Thyroid cancer pathway
Melanoma pathway
Bladder cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Non-small cell lung cancer pathway
INOH
IGF1 signaling pathway pathway
NGF signaling pathway pathway
GPCR signaling pathway
TGF-beta signaling pathway
PDGF signaling pathway pathway
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
PID BIOCARTA
Role of ?-arrestins in the activation and targeting of map kinases [Biocarta view]
Aspirin blocks signaling pathway involved in platelet activation [Biocarta view]
Mechanism of gene regulation by peroxisome proliferators via ppara [Biocarta view]
Ccr3 signaling in eosinophils [Biocarta view]
Phospholipids as signalling intermediaries [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Human cytomegalovirus and map kinase pathways [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Transcription factor creb and its extracellular signals [Biocarta view]
Role of erbb2 in signal transduction and oncology [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Agrin in postsynaptic differentiation [Biocarta view]
Regulation of splicing through sam68 [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Melanocyte development and pigmentation pathway [Biocarta view]
Trefoil factors initiate mucosal healing [Biocarta view]
Regulation of eif-4e and p70s6 kinase [Biocarta view]
How progesterone initiates the oocyte maturation [Biocarta view]
Stat3 signaling pathway [Biocarta view]
Mcalpain and friends in cell motility [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
Roles of ? arrestin dependent recruitment of src kinases in gpcr signaling [Biocarta view]
Phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway [Biocarta view]
Role of mal in rho-mediated activation of srf [Biocarta view]
Erk and pi-3 kinase are necessary for collagen binding in corneal epithelia [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
Sprouty regulation of tyrosine kinase signals [Biocarta view]
Role of erk5 in neuronal survival pathway [Biocarta view]
Ceramide signaling pathway [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
Erk1/erk2 mapk signaling pathway [Biocarta view]
Influence of ras and rho proteins on g1 to s transition [Biocarta view]
Cadmium induces dna synthesis and proliferation in macrophages [Biocarta view]
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
Nongenotropic Androgen signaling
Ceramide signaling pathway
BMP receptor signaling
Presenilin action in Notch and Wnt signaling
Signaling events mediated by focal adhesion kinase
Class IB PI3K non-lipid kinase events
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt P28482
TrEMBL
UniProt Splice Variant
Entrez Gene 5594
UniGene Hs.431850 Hs.592187
RefSeq NM_002745 NM_138957
HUGO HGNC:6871
OMIM 176948
CCDS CCDS13795
HPRD 01496
IMGT
EMBL AP000553 AP000554 AP000555 BC017832 DQ399292 M84489 Z11694 Z11695
GenPept AAA58459 AAH17832 ABD60303 CAA77752 CAA77753
RNA Seq Atlas 5594