Version 5.4
Homo sapiens Gene: PARP2
Summary
InnateDB Gene IDBG-2169.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARP2
Gene Name poly (ADP-ribose) polymerase 2
Synonyms ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2; PARP-2
Species Homo sapiens
Ensembl Gene ENSG00000129484
Encoded Proteins
IDBP-2171
poly (ADP-ribose) polymerase 2
IDBP-360625
poly (ADP-ribose) polymerase 2
IDBP-585492
poly (ADP-ribose) polymerase 2
IDBP-594942
poly (ADP-ribose) polymerase 2
IDBP-594172
poly (ADP-ribose) polymerase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:20343582-20357905
Strand Forward strand
Band q11.2
Transcripts
ENST00000250416 ENSP00000250416
ENST00000429687 ENSP00000392972
ENST00000529465 ENSP00000431867
ENST00000527915 ENSP00000432283
ENST00000528465
ENST00000555140
ENST00000527384
ENST00000532299
ENST00000539930 ENSP00000445524
ENST00000530598
ENST00000534664
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 123 [view]
Protein-Protein 120 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006471 protein ADP-ribosylation
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036023
View Gene Order
ENSBTAG00000009374
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03410
Base excision repair pathway
INOH
PID NCI
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.409412
RefSeq NM_001042618 NM_005484 XM_005267247
HUGO
OMIM
CCDS CCDS41910 CCDS45077
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca