Version 5.4
Homo sapiens Gene: CD70
Summary
InnateDB Gene IDBG-21699.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD70
Gene Name CD70 molecule
Synonyms CD27L; CD27LG; TNFSF7
Species Homo sapiens
Ensembl Gene ENSG00000125726
Encoded Proteins
IDBP-21701
CD70 molecule
IDBP-367400
CD70 molecule
IDBP-766048
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:6583183-6604103
Strand Reverse strand
Band p13.3
Transcripts
ENST00000245903 ENSP00000245903
ENST00000423145 ENSP00000395294
ENST00000597430 ENSP00000470805
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008283 cell proliferation
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019489
View Gene Order
ENSBTAG00000009752
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt P32970
TrEMBL B4DPR8 M0QZW2
UniProt Splice Variant
Entrez Gene 970
UniGene Hs.715224
RefSeq NM_001252
HUGO HGNC:11937
OMIM 602840
CCDS CCDS12170
HPRD
IMGT
EMBL AC008760 AK298467 BC000725 BT007211 CH471139 EF064709 L08096 S69339
GenPept AAA36175 AAB30121 AAH00725 AAP35875 ABK41892 BAG60680 EAW69074
RNA Seq Atlas 970

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca