InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TNFSF14

Summary

InnateDB Gene

IDBG-21748.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFSF14

Gene Name

tumor necrosis factor (ligand) superfamily, member 14

Synonyms

CD258; HVEML; LIGHT; LTg; TR2

Species

Homo sapiens

Ensembl Gene

ENSG00000125735

Encoded Proteins

IDBP-21750

tumor necrosis factor (ligand) superfamily, member 14

IDBP-763115

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:6661253-6670588

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000245912	ENSP00000245912
ENST00000599359	ENSP00000469049

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process

GO:0006915	apoptotic process
GO:0006955	immune response
GO:0007165	signal transduction
GO:0008588	release of cytoplasmic sequestered NF-kappaB
GO:0010820	positive regulation of T cell chemotaxis
GO:0031295	T cell costimulation
GO:0042098	T cell proliferation
GO:0042110	T cell activation
GO:0043029	T cell homeostasis
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000005824

View Gene Order

ENSBTAG00000012223

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

O43557

TrEMBL

UniProt Splice Variant

Entrez Gene

8740

UniGene

Hs.129708

RefSeq

NM_003807 NM_172014 XM_005259670

HUGO

HGNC:11930

OMIM

604520

CCDS

CCDS12171 CCDS45939

HPRD

05157

IMGT

EMBL

AC008760 AF036581 AF064090 AK292037 AY028261 AY358812 CH471139 CR541854 CR541871

GenPept

AAC25169 AAC39563 AAK26160 AAQ89171 BAF84726 CAG46652 CAG46669 EAW69072

RNA Seq Atlas

8740