Homo sapiens Gene: KAT2B
InnateDB Gene IDBG-21805.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KAT2B
Gene Name K(lysine) acetyltransferase 2B
Synonyms CAF; P/CAF; PCAF
Species Homo sapiens
Ensembl Gene ENSG00000114166
Encoded Proteins
K(lysine) acetyltransferase 2B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
KAT2B is a histone acetylase and a phorbol ester-inducible co-activator of the interferon (IFN) regulatory factor (IRF) proteins which contributes to the establishment of type I IFN responsiveness.
Entrez Gene
Summary CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:20040023-20154404
Strand Forward strand
Band p24.3
ENST00000263754 ENSP00000263754
Number of Interactions This gene and/or its encoded proteins are associated with 218 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 218 [view]
Protein-Protein 206 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 4 [view]
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0004468 lysine N-acetyltransferase activity
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 protein binding
GO:0008080 N-acetyltransferase activity
GO:0008134 transcription factor binding
GO:0016407 acetyltransferase activity
GO:0019901 protein kinase binding
GO:0032403 protein complex binding
GO:0042826 histone deacetylase binding
Biological Process
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006473 protein acetylation
GO:0007050 cell cycle arrest
GO:0007219 Notch signaling pathway
GO:0008285 negative regulation of cell proliferation
GO:0010467 gene expression
GO:0010835 regulation of protein ADP-ribosylation
GO:0016032 viral process
GO:0016573 histone acetylation
GO:0018076 N-terminal peptidyl-lysine acetylation
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0032869 cellular response to insulin stimulus
GO:0043966 histone H3 acetylation
GO:0043970 histone H3-K9 acetylation
GO:0045087 innate immune response (InnateDB)
GO:0045722 positive regulation of gluconeogenesis
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048511 rhythmic process
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0000125 PCAF complex
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0031672 A band
GO:0031674 I band
GO:0042641 actomyosin
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
AndrogenReceptor pathway
Notch pathway
TGF_beta_Receptor pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Pre-NOTCH Transcription and Translation pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
RNA Polymerase I Transcription Initiation pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
Notch-HLH transcription pathway pathway
Generic Transcription Pathway pathway
HATs acetylate histones pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
RNA Polymerase I Transcription pathway
Pre-NOTCH Expression and Processing pathway
Signaling by NOTCH1 in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
RNA Polymerase I Promoter Clearance pathway
Signal Transduction pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Chromatin organization pathway
Signaling by NOTCH pathway
Chromatin modifying enzymes pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Gene Expression pathway
Disease pathway
Notch signaling pathway pathway
FoxO family signaling
Signaling events mediated by HDAC Class I
p53 pathway
E2F transcription factor network
Retinoic acid receptors-mediated signaling
Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class III
Regulation of Androgen receptor activity
UniProt Splice Variant
Entrez Gene
UniGene Hs.533055 Hs.617804
RefSeq NM_003884 XM_005265528
HPRD 06780
RNA Seq Atlas