InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KAT2B

Summary

InnateDB Gene

IDBG-21805.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KAT2B

Gene Name

K(lysine) acetyltransferase 2B

Synonyms

CAF; P/CAF; PCAF

Species

Homo sapiens

Ensembl Gene

ENSG00000114166

Encoded Proteins

IDBP-21807

K(lysine) acetyltransferase 2B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 10022868

KAT2B is a histone acetylase and a phorbol ester-inducible co-activator of the interferon (IFN) regulatory factor (IRF) proteins which contributes to the establishment of type I IFN responsiveness.

Entrez Gene

Summary

CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:20040023-20154404

Strand

Forward strand

Band

p24.3

Transcripts

ENST00000263754	ENSP00000263754
ENST00000426228
ENST00000469085
ENST00000468111
ENST00000468400

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 218 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	218 [view]
Protein-Protein	206 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0004468	lysine N-acetyltransferase activity
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0008080	N-acetyltransferase activity
GO:0008134	transcription factor binding
GO:0016407	acetyltransferase activity
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0042826	histone deacetylase binding

Biological Process

GO:0006325	chromatin organization
GO:0006338	chromatin remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006360	transcription from RNA polymerase I promoter
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006473	protein acetylation
GO:0007050	cell cycle arrest
GO:0007219	Notch signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0010467	gene expression
GO:0010835	regulation of protein ADP-ribosylation
GO:0016032	viral process
GO:0016573	histone acetylation
GO:0018076	N-terminal peptidyl-lysine acetylation
GO:0018393	internal peptidyl-lysine acetylation
GO:0018394	peptidyl-lysine acetylation
GO:0032869	cellular response to insulin stimulus
GO:0043966	histone H3 acetylation
GO:0043970	histone H3-K9 acetylation
GO:0045087	innate immune response (InnateDB)
GO:0045722	positive regulation of gluconeogenesis
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048511	rhythmic process

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0000125	PCAF complex
GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
GO:0031672	A band
GO:0031674	I band
GO:0042641	actomyosin