Version 5.4
Homo sapiens Gene: MOS
Summary
InnateDB Gene IDBG-22394.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MOS
Gene Name v-mos Moloney murine sarcoma viral oncogene homolog
Synonyms MSV
Species Homo sapiens
Ensembl Gene ENSG00000172680
Encoded Proteins
IDBP-22396
v-mos Moloney murine sarcoma viral oncogene homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:56112942-56113982
Strand Reverse strand
Band q12.1
Transcripts
ENST00000311923 ENSP00000310722
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0000212 meiotic spindle organization
GO:0006325 chromatin organization
GO:0006468 protein phosphorylation
GO:0040020 regulation of meiosis
GO:0046777 protein autophosphorylation
GO:0051296 establishment of meiotic spindle orientation
GO:1902103 negative regulation of metaphase/anaphase transition of meiotic cell cycle
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000078365
View Gene Order
ENSBTAG00000019145
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04010
MAPK signaling pathway pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04114
Oocyte meiosis pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt P00540
TrEMBL
UniProt Splice Variant
Entrez Gene 4342
UniGene Hs.533432
RefSeq NM_005372
HUGO HGNC:7199
OMIM 190060
CCDS CCDS6164
HPRD
IMGT
EMBL BC069569 BC069590 BC106737 BC106738 J00119
GenPept AAA52029 AAH69569 AAH69590 AAI06738 AAI06739
RNA Seq Atlas 4342

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca