Homo sapiens Gene: SLCO1B3 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-22433.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | SLCO1B3 | ||||||||||||||
Gene Name | solute carrier organic anion transporter family, member 1B3 | ||||||||||||||
Synonyms | |||||||||||||||
Species | Homo sapiens | ||||||||||||||
Ensembl Gene | ENSG00000111700 | ||||||||||||||
Encoded Proteins |
solute carrier organic anion transporter family, member 1B3
solute carrier organic anion transporter family, member 1B3
solute carrier organic anion transporter family, member 1B3
solute carrier organic anion transporter family, member 1B3
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. [provided by RefSeq, Feb 2012] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 12:20810702-20916911 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | p12.2 | ||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
No orthologs found for this gene | |||||||||||||||
Pathways | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Transport of organic anions pathway
Transport of vitamins, nucleosides, and related molecules pathway
Recycling of bile acids and salts pathway
Transmembrane transport of small molecules pathway
Metabolism of lipids and lipoproteins pathway
Bile acid and bile salt metabolism pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
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KEGG |
Bile secretion pathway
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INOH | |||||||||||||||
PID NCI | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | |||||||||||||||
UniGene | Hs.504966 | ||||||||||||||
RefSeq | NM_019844 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS8684 | ||||||||||||||
HPRD | 12021 | ||||||||||||||
IMGT | |||||||||||||||
EMBL | |||||||||||||||
GenPept | |||||||||||||||
RNA Seq Atlas | |||||||||||||||