Homo sapiens Gene: SLCO1B1
Summary
InnateDB Gene IDBG-22549.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLCO1B1
Gene Name solute carrier organic anion transporter family, member 1B1
Synonyms HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2; OATPC; SLC21A6;
Species Homo sapiens
Ensembl Gene ENSG00000134538
Encoded Proteins
solute carrier organic anion transporter family, member 1B1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:21131202-21239246
Strand Forward strand
Band p12.1
Transcripts
ENST00000256958 ENSP00000256958
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0015347 sodium-independent organic anion transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0008206 bile acid metabolic process
GO:0015711 organic anion transport
GO:0015721 bile acid and bile salt transport
GO:0043252 sodium-independent organic anion transport
GO:0044281 small molecule metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Metabolism of lipids and lipoproteins pathway
Transport of vitamins, nucleosides, and related molecules pathway
Bile acid and bile salt metabolism pathway
Recycling of bile acids and salts pathway
Transport of organic anions pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
KEGG
Bile secretion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y6L6
TrEMBL A0A024RAU7 K4P403
UniProt Splice Variant
Entrez Gene 10599
UniGene Hs.449738
RefSeq NM_006446
HUGO HGNC:10959
OMIM 604843
CCDS CCDS8685
HPRD
IMGT
EMBL AB026257 AF060500 AF205071 AJ132573 AJ400749 AJ400750 AJ400751 AJ400752 AJ400753 AJ400754 AJ400755 AJ400756 AJ400757 AJ400758 AJ400759 AJ400760 AJ400761 AJ400762 AK312970 AY945934 BC114376 CH471094 JX547014
GenPept AAD38323 AAF20212 AAI14377 AAX20114 AFV58025 BAA78639 BAG35809 CAB62577 CAB97007 EAW96420 EAW96421
RNA Seq Atlas 10599