Version 5.4
Homo sapiens Gene: PENK
Summary
InnateDB Gene IDBG-22561.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PENK
Gene Name proenkephalin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000181195
Encoded Proteins
IDBP-22563
proenkephalin
IDBP-371009
proenkephalin
IDBP-477936
proenkephalin
IDBP-483308
proenkephalin
IDBP-483456
proenkephalin
IDBP-478668
proenkephalin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 8:56436674-56446734
Strand Reverse strand
Band q12.1
Transcripts
ENST00000314922 ENSP00000324248
ENST00000451791 ENSP00000400894
ENST00000517415 ENSP00000430268
ENST00000520589
ENST00000523274
ENST00000518974 ENSP00000428012
ENST00000523051 ENSP00000429326
ENST00000518770 ENSP00000430592
ENST00000521153
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 1 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001515 opioid peptide activity
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
Biological Process
GO:0001662 behavioral fear response
GO:0001964 startle response
GO:0002118 aggressive behavior
GO:0007165 signal transduction
GO:0007218 neuropeptide signaling pathway
GO:0007626 locomotory behavior
GO:0019233 sensory perception of pain
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000045573
View Gene Order
ENSBTAG00000004924
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
PID NCI
ap1_pathway
AP-1 transcription factor network
Cross-References
SwissProt P01210
TrEMBL A0A024R7V4 E5RFR1 E5RIP6 E5RJ72 H0YBT5
UniProt Splice Variant
Entrez Gene 5179
UniGene Hs.104920 Hs.339831 Hs.733358
RefSeq NM_001135690 NM_006211
HUGO HGNC:8831
OMIM 131330
CCDS CCDS6168
HPRD
IMGT
EMBL AC023464 AK314908 BC032505 CH471068 CR541808 CR541828 J00122 J00123 V00509
GenPept AAB59409 AAH32505 BAG37420 CAA23767 CAG46607 CAG46627 EAW86785 EAW86787
RNA Seq Atlas 5179

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca