Version 5.4
Homo sapiens Gene: NGLY1
Summary
InnateDB Gene IDBG-22696.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NGLY1
Gene Name N-glycanase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000151092
Encoded Proteins
IDBP-22698
N-glycanase 1
IDBP-22700
N-glycanase 1
IDBP-22702
N-glycanase 1
IDBP-237037
N-glycanase 1
IDBP-368243
N-glycanase 1
IDBP-368249
N-glycanase 1
IDBP-368263
N-glycanase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that catalyzes hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue to N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. The encoded enzyme may play a role in the proteasome-mediated degradation of misfolded glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:25718944-25790039
Strand Reverse strand
Band p24.2
Transcripts
ENST00000308710 ENSP00000307980
ENST00000280700 ENSP00000280700
ENST00000280699 ENSP00000280699
ENST00000396649 ENSP00000379886
ENST00000417874 ENSP00000389888
ENST00000428257 ENSP00000387430
ENST00000427041 ENSP00000412946
ENST00000489271
ENST00000493324
ENST00000467224
ENST00000496726
ENST00000461491
ENST00000474611
ENST00000478991
ENST00000463611
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006289 nucleotide-excision repair
GO:0006516 glycoprotein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021785
View Gene Order
ENSBTAG00000003793
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.719515 Hs.743367
RefSeq NM_001145293 NM_001145294 NM_001145295 NM_018297
HUGO
OMIM
CCDS CCDS33719 CCDS46777 CCDS46778 CCDS46779
HPRD 10118
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca