Homo sapiens Gene: GCGR
Summary
InnateDB Gene IDBG-227533.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCGR
Gene Name glucagon receptor
Synonyms GGR; GL-R;
Species Homo sapiens
Ensembl Gene ENSG00000215644
Encoded Proteins
glucagon receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:81804132-81814013
Strand Forward strand
Band q25.3
Transcripts
ENST00000400723 ENSP00000383558
ENST00000570996 ENSP00000460976
ENST00000574283
ENST00000573428 ENSP00000458930
ENST00000571425
ENST00000572185
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004967 glucagon receptor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0017046 peptide hormone binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006112 energy reserve metabolic process
GO:0006887 exocytosis
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007584 response to nutrient
GO:0008217 regulation of blood pressure
GO:0009755 hormone-mediated signaling pathway
GO:0042593 glucose homeostasis
GO:0042594 response to starvation
GO:0043547 positive regulation of GTPase activity
GO:0044281 small molecule metabolic process
GO:0070873 regulation of glycogen metabolic process
GO:0071377 cellular response to glucagon stimulus
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Integration of energy metabolism pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Glucagon signaling in metabolic regulation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Glucagon-type ligand receptors pathway
GPCR ligand binding pathway
Metabolism pathway
Class B/2 (Secretin family receptors) pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.208
RefSeq NM_000160 XM_006722276 XM_006722277
HUGO
OMIM
CCDS CCDS54177
HPRD 00678
IMGT
EMBL
GenPept
RNA Seq Atlas