Version 5.4
Homo sapiens Gene: APOBR
Summary
InnateDB Gene IDBG-22787.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOBR
Gene Name apolipoprotein B receptor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000184730
Encoded Proteins
IDBP-373942
apolipoprotein B receptor
IDBP-754517
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:28494649-28498970
Strand Forward strand
Band p12.1
Transcripts
ENST00000431282 ENSP00000416094
ENST00000564831 ENSP00000457539
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0030229 very-low-density lipoprotein particle receptor activity
Biological Process
GO:0006641 triglyceride metabolic process
GO:0006869 lipid transport
GO:0006898 receptor-mediated endocytosis
GO:0008203 cholesterol metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034361 very-low-density lipoprotein particle
GO:0034362 low-density lipoprotein particle
GO:0042627 chylomicron
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042759
View Gene Order
ENSBTAG00000018011
Not yet available
Cross-References
SwissProt Q0VD83
TrEMBL
UniProt Splice Variant
Entrez Gene 55911
UniGene Hs.200333
RefSeq NM_018690
HUGO HGNC:24087
OMIM 605220
CCDS CCDS58442
HPRD 05561
IMGT
EMBL AC138894 AF141332 AF141333 AK075085 BC119786 BC119788
GenPept AAF76255 AAF76256 AAI19787 AAI19789
RNA Seq Atlas 55911

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca