Homo sapiens Gene: POR
Summary
InnateDB Gene IDBG-22810.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POR
Gene Name P450 (cytochrome) oxidoreductase
Synonyms CPR; CYPOR; P450R;
Species Homo sapiens
Ensembl Gene ENSG00000127948
Encoded Proteins
P450 (cytochrome) oxidoreductase
P450 (cytochrome) oxidoreductase
P450 (cytochrome) oxidoreductase
P450 (cytochrome) oxidoreductase
P450 (cytochrome) oxidoreductase
P450 (cytochrome) oxidoreductase
P450 (cytochrome) oxidoreductase
P450 (cytochrome) oxidoreductase
P450 (cytochrome) oxidoreductase
P450 (cytochrome) oxidoreductase
P450 (cytochrome) oxidoreductase
P450 (cytochrome) oxidoreductase
P450 (cytochrome) oxidoreductase
P450 (cytochrome) oxidoreductase
P450 (cytochrome) oxidoreductase
P450 (cytochrome) oxidoreductase
P450 (cytochrome) oxidoreductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:75899200-75986855
Strand Forward strand
Band q11.23
Transcripts
ENST00000394893 ENSP00000378355
ENST00000453773 ENSP00000395813
ENST00000439963 ENSP00000390540
ENST00000448410 ENSP00000399409
ENST00000421059 ENSP00000409881
ENST00000412521 ENSP00000409238
ENST00000414186 ENSP00000399327
ENST00000432753 ENSP00000389409
ENST00000449920 ENSP00000399556
ENST00000418341 ENSP00000389719
ENST00000454934 ENSP00000414263
ENST00000412064 ENSP00000404731
ENST00000447222 ENSP00000393527
ENST00000426184 ENSP00000400964
ENST00000439297 ENSP00000403494
ENST00000439269 ENSP00000412490
ENST00000461988 ENSP00000419970
ENST00000471238
ENST00000475509
ENST00000460892
ENST00000496888
ENST00000487247
ENST00000495770
ENST00000493973
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003958 NADPH-hemoprotein reductase activity
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008941 nitric oxide dioxygenase activity
GO:0009055 electron carrier activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0016787 hydrolase activity
GO:0019899 enzyme binding
GO:0047726 iron-cytochrome-c reductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0003420 regulation of growth plate cartilage chondrocyte proliferation
GO:0007584 response to nutrient
GO:0009437 carnitine metabolic process
GO:0009812 flavonoid metabolic process
GO:0018393 internal peptidyl-lysine acetylation
GO:0019395 fatty acid oxidation
GO:0032332 positive regulation of chondrocyte differentiation
GO:0032770 positive regulation of monooxygenase activity
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043602 nitrate catabolic process
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0045880 positive regulation of smoothened signaling pathway
GO:0046210 nitric oxide catabolic process
GO:0055114 oxidation-reduction process
GO:0060192 negative regulation of lipase activity
GO:0070988 demethylation
GO:0071371 cellular response to gonadotropin stimulus
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0090031 positive regulation of steroid hormone biosynthetic process
GO:0090181 regulation of cholesterol metabolic process
GO:0090346 cellular organofluorine metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
Oxidative stress induced gene expression via nrf2 [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.354056 Hs.708842
RefSeq NM_000941
HUGO
OMIM
CCDS CCDS5579
HPRD 00485
IMGT
EMBL
GenPept
RNA Seq Atlas