Version 5.4
Homo sapiens Gene: ALOX12
Summary
InnateDB Gene IDBG-22829.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALOX12
Gene Name arachidonate 12-lipoxygenase
Synonyms 12-LOX; 12S-LOX; LOG12
Species Homo sapiens
Ensembl Gene ENSG00000108839
Encoded Proteins
IDBP-22833
arachidonate 12-lipoxygenase
IDBP-760347
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:6996065-7010736
Strand Forward strand
Band p13.1
Transcripts
ENST00000251535 ENSP00000251535
ENST00000406228
ENST00000480801 ENSP00000467033
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004052 arachidonate 12-lipoxygenase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016165 lipoxygenase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872 metal ion binding
GO:0047977 hepoxilin-epoxide hydrolase activity
GO:0051120 hepoxilin A3 synthase activity
Biological Process
GO:0006928 cellular component movement
GO:0007568 aging
GO:0008284 positive regulation of cell proliferation
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0010942 positive regulation of cell death
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0019395 fatty acid oxidation
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0042554 superoxide anion generation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043651 linoleic acid metabolic process
GO:0044281 small molecule metabolic process
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045909 positive regulation of vasodilation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051121 hepoxilin metabolic process
GO:0051122 hepoxilin biosynthetic process
GO:0051901 positive regulation of mitochondrial depolarization
GO:0055114 oxidation-reduction process
GO:0061436 establishment of skin barrier
GO:0071396 cellular response to lipid
GO:0072593 reactive oxygen species metabolic process
GO:0090331 negative regulation of platelet aggregation
GO:1901751 leukotriene A4 metabolic process
GO:2001300 lipoxin metabolic process
GO:2001303 lipoxin A4 biosynthetic process
GO:2001306 lipoxin B4 biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0042383 sarcolemma
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000320
View Gene Order
ENSBTAG00000021933
Not yet available
Pathways
NETPATH
REACTOME
REACT_150320
Synthesis of Lipoxins (LX) pathway
REACT_150201
Synthesis of 12-eicosatetraenoic acid derivatives pathway
REACT_150292
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
INOH
INOH website
Prostaglandin Leukotriene metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654431
RefSeq NM_000697 XM_006721496 XM_006721497
HUGO
OMIM
CCDS CCDS11084
HPRD 01066
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca