InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPL17

Summary

InnateDB Gene

IDBG-228335.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPL17

Gene Name

60S ribosomal protein L17 isoform a

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000215472

Encoded Proteins

IDBP-3234

ribosomal protein L17

IDBP-369187

ribosomal protein L17

IDBP-727801

IDBP-727705

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This locus represents naturally occurring read-through transcription between the neighboring RPL17 (ribosomal protein L17) and C18orf32 (chromosome 18 open reading frame 32) genes. Alternative splicing results in multiple transcript variants. The encoded isoforms share sequence identity with the RPL17 protein, but they include frameshifted C-terminal regions derived from the downstream gene exons. [provided by RefSeq, Dec 2010] Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:49481681-49491586

Strand

Reverse strand

Band

q21.1

Transcripts

ENST00000332968	ENSP00000352143
ENST00000418495	ENSP00000397798
ENST00000584895	ENSP00000463379
ENST00000577910	ENSP00000463338

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0022625	cytosolic large ribosomal subunit

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

KEGG

hsa03010

Ribosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.374588 Hs.603040

RefSeq

NM_001199355 NM_000985 NM_001035006 NM_001199340 NM_001199341 NM_001199342 NM_001199343 NM_001199344 NM_001199345

HUGO

OMIM

CCDS

CCDS45865 CCDS58622 CCDS62443 CCDS56070

HPRD

04715

IMGT

EMBL

GenPept

RNA Seq Atlas