InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC4A4

Summary

InnateDB Gene

IDBG-22865.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC4A4

Gene Name

solute carrier family 4, sodium bicarbonate cotransporter, member 4

Synonyms

hhNMC; HNBC1; KNBC; NBC1; NBC2; NBCe1-A; pNBC; SLC4A5

Species

Homo sapiens

Ensembl Gene

ENSG00000080493

Encoded Proteins

IDBP-22867

solute carrier family 4, sodium bicarbonate cotransporter, member 4

IDBP-22869

solute carrier family 4, sodium bicarbonate cotransporter, member 4

IDBP-22871

solute carrier family 4, sodium bicarbonate cotransporter, member 4

IDBP-370159

solute carrier family 4, sodium bicarbonate cotransporter, member 4

IDBP-476789

solute carrier family 4, sodium bicarbonate cotransporter, member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:71187286-71572087

Strand

Forward strand

Band

q13.3

Transcripts

ENST00000264485	ENSP00000264485
ENST00000351898	ENSP00000307349
ENST00000340595	ENSP00000344272
ENST00000425175	ENSP00000393557
ENST00000514331
ENST00000512686	ENSP00000422400

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005452	inorganic anion exchanger activity
GO:0005515	protein binding
GO:0008509	anion transmembrane transporter activity
GO:0008510	sodium:bicarbonate symporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0006820	anion transport
GO:0015701	bicarbonate transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000060961

View Gene Order

ENSBTAG00000002348

Not yet available

Pathways

NETPATH

REACTOME

REACT_19298

Bicarbonate transporters pathway

REACT_19397

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

hsa04964

Proximal tubule bicarbonate reclamation pathway

hsa04972

Pancreatic secretion pathway

hsa04976

Bile secretion pathway

INOH

PID NCI

Cross-References

SwissProt

Q9Y6R1

TrEMBL

A0A024RD97 A5JJ20

UniProt Splice Variant

Entrez Gene

8671

UniGene

Hs.5462 Hs.592708

RefSeq

NM_001098484 NM_001134742 NM_003759 XM_005265704 XM_006714398 XM_006714399

HUGO

HGNC:11030

OMIM

603345

CCDS

CCDS3549 CCDS43236 CCDS47071

HPRD

IMGT

EMBL

AB470072 AC019089 AC079230 AC096713 AC110783 AC112226 AF007216 AF011390 AF053753 AF053754 AF069510 AF157492 AF310248 BC030977 CH471057 EF531618

GenPept

AAC39840 AAC51645 AAD42020 AAF21718 AAF21719 AAF80343 AAG47773 AAH30977 ABQ43327 BAH58226 EAX05642 EAX05643

RNA Seq Atlas

8671