Homo sapiens Gene: SLC4A4
Summary
InnateDB Gene IDBG-22865.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC4A4
Gene Name solute carrier family 4, sodium bicarbonate cotransporter, member 4
Synonyms hhNMC; HNBC1; KNBC; NBC1; NBC2; NBCe1-A; pNBC; SLC4A5;
Species Homo sapiens
Ensembl Gene ENSG00000080493
Encoded Proteins
solute carrier family 4, sodium bicarbonate cotransporter, member 4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:71187286-71572087
Strand Forward strand
Band q13.3
Transcripts
ENST00000264485 ENSP00000264485
ENST00000351898 ENSP00000307349
ENST00000340595 ENSP00000344272
ENST00000425175 ENSP00000393557
ENST00000514331
ENST00000512686 ENSP00000422400
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005452 inorganic anion exchanger activity
GO:0005515 protein binding
GO:0008509 anion transmembrane transporter activity
GO:0008510 sodium:bicarbonate symporter activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0006820 anion transport
GO:0015701 bicarbonate transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Bicarbonate transporters pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
SLC-mediated transmembrane transport pathway
KEGG
Proximal tubule bicarbonate reclamation pathway
Pancreatic secretion pathway
Bile secretion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.5462 Hs.592708
RefSeq NM_001098484 NM_001134742 NM_003759 XM_005265704 XM_006714398 XM_006714399
HUGO
OMIM
CCDS CCDS3549 CCDS43236 CCDS47071
HPRD 04516
IMGT
EMBL
GenPept
RNA Seq Atlas