InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAB2A

Summary

InnateDB Gene

IDBG-22906.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB2A

Gene Name

RAB2A, member RAS oncogene family

Synonyms

LHX; RAB2

Species

Homo sapiens

Ensembl Gene

ENSG00000104388

Encoded Proteins

IDBP-22908

RAB2A, member RAS oncogene family

IDBP-371240

RAB2A, member RAS oncogene family

IDBP-585701

RAB2A, member RAS oncogene family

IDBP-599164

RAB2A, member RAS oncogene family

IDBP-587094

RAB2A, member RAS oncogene family

IDBP-594357

RAB2A, member RAS oncogene family

IDBP-598756

RAB2A, member RAS oncogene family

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:60516857-60623627

Strand

Forward strand

Band

q12.1

Transcripts

ENST00000262646	ENSP00000262646
ENST00000396696
ENST00000429861
ENST00000452437	ENSP00000398054
ENST00000481569
ENST00000466595	ENSP00000432855
ENST00000531289	ENSP00000431846
ENST00000529579	ENSP00000431589
ENST00000531098	ENSP00000432735
ENST00000534260	ENSP00000433875
ENST00000525529
ENST00000530071

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0019003	GDP binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000047187

View Gene Order

Pathways

NETPATH

REACTOME

REACT_1100

Golgi Cisternae Pericentriolar Stack Reorganization pathway

REACT_115566

Cell Cycle pathway

REACT_910

M Phase pathway

REACT_765

Mitotic Prophase pathway

REACT_152

Cell Cycle, Mitotic pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.369017 Hs.618687 Hs.655034 Hs.730962

RefSeq

NM_001242644 NM_002865

HUGO

OMIM

CCDS

CCDS56537 CCDS6175

HPRD

01539

IMGT

EMBL

GenPept

RNA Seq Atlas