InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: JAG2

Summary

InnateDB Gene

IDBG-23019.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

JAG2

Gene Name

jagged 2

Synonyms

HJ2; SER2

Species

Homo sapiens

Ensembl Gene

ENSG00000184916

Encoded Proteins

IDBP-23021

jagged 2

IDBP-23023

jagged 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:105140981-105168824

Strand

Reverse strand

Band

q32.33

Transcripts

ENST00000331782	ENSP00000328169
ENST00000347004	ENSP00000328566
ENST00000546616
ENST00000553244
ENST00000553051

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001501	skeletal system development
GO:0001701	in utero embryonic development
GO:0003016	respiratory system process
GO:0007049	cell cycle
GO:0007154	cell communication
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0009912	auditory receptor cell fate commitment
GO:0016331	morphogenesis of embryonic epithelium
GO:0030154	cell differentiation
GO:0030155	regulation of cell adhesion
GO:0030217	T cell differentiation
GO:0030334	regulation of cell migration
GO:0042127	regulation of cell proliferation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042492	gamma-delta T cell differentiation
GO:0045061	thymic T cell selection
GO:1990134	epithelial cell apoptotic process involved in palatal shelf morphogenesis