Version 5.4
Homo sapiens Gene: AZI2
Summary
InnateDB Gene IDBG-23171.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AZI2
Gene Name 5-azacytidine induced 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163512
Encoded Proteins
IDBP-23177
5-azacytidine induced 2
IDBP-368987
5-azacytidine induced 2
IDBP-369013
5-azacytidine induced 2
IDBP-369016
5-azacytidine induced 2
IDBP-369018
5-azacytidine induced 2
IDBP-369022
5-azacytidine induced 2
IDBP-481059
5-azacytidine induced 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17142768
AZI2 participates in both the TLR3-mediated and the cytoplasmic DDX58 (RIG-I) dsRNA recognition pathways in type-1 interferon (IFN) induction by binding to MAVS, DDX58 and IFIH1 (MDA5).
Entrez Gene
Summary AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:28315003-28349127
Strand Reverse strand
Band p24.1
Transcripts
ENST00000295748
ENST00000334100 ENSP00000335609
ENST00000429369 ENSP00000403133
ENST00000420543 ENSP00000391696
ENST00000457172 ENSP00000389577
ENST00000414162 ENSP00000412820
ENST00000415852 ENSP00000416380
ENST00000479665 ENSP00000419371
ENST00000476174
ENST00000492044
ENST00000463512
ENST00000488978
ENST00000470234
ENST00000462936
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 38 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0001816 cytokine production
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0032607 interferon-alpha production
GO:0032609 interferon-gamma production
GO:0032635 interleukin-6 production
GO:0032640 tumor necrosis factor production
GO:0042110 T cell activation
GO:0044565 dendritic cell proliferation
GO:0045087 innate immune response (InnateDB)
GO:0097028 dendritic cell differentiation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039285
View Gene Order
ENSBTAG00000004117
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04622
RIG-I-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.600837 Hs.610647 Hs.706676 Hs.714670
RefSeq NM_001134432 NM_001134433 NM_001271650 NM_022461 XM_005265392 XM_005265393
HUGO
OMIM
CCDS CCDS2647 CCDS46782 CCDS46783
HPRD 10577
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca