Version 5.4
Homo sapiens Gene: RETN
Summary
InnateDB Gene IDBG-23228.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RETN
Gene Name resistin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000104918
Encoded Proteins
IDBP-23230
resistin
IDBP-23232
resistin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:7669044-7670454
Strand Forward strand
Band p13.2
Transcripts
ENST00000221515 ENSP00000221515
ENST00000381324 ENSP00000370725
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0007568 aging
GO:0008150 biological_process
GO:0009612 response to mechanical stimulus
GO:0010714 positive regulation of collagen metabolic process
GO:0014911 positive regulation of smooth muscle cell migration
GO:0032868 response to insulin
GO:0045444 fat cell differentiation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050806 positive regulation of synaptic transmission
GO:2000252 negative regulation of feeding behavior
GO:2000872 positive regulation of progesterone secretion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q76B53
UniProt Splice Variant
Entrez Gene 56729
UniGene
RefSeq NM_001193374 NM_020415
HUGO HGNC:20389
OMIM 605565
CCDS CCDS12182
HPRD 05714
IMGT
EMBL AB111910 AC008763
GenPept BAD04068
RNA Seq Atlas 56729

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca