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InnateDB Gene
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IDBG-232806.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MEG3
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Gene Name
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maternally expressed 3 (non-protein coding)
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Synonyms
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Species
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Homo sapiens
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Ensembl Gene
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ENSG00000214548
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Encoded Proteins
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Protein Structure
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Useful resources
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Stemformatics
EHFPI
ImmGen
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| Summary |
This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]
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| Type |
lincRNA
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Genomic Location
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Chromosome 14:100779410-100861031
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Strand
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Forward strand
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Band
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q32.2
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Transcripts
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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No orthologs found for this gene |
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SwissProt
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TrEMBL
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UniProt Splice Variant
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Entrez Gene
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UniGene
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Hs.604612
Hs.654863
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RefSeq
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HUGO
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OMIM
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CCDS
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| HPRD |
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IMGT
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EMBL
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GenPept
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RNA Seq Atlas
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Version 5.4