Homo sapiens Gene: DTX2
Summary
InnateDB Gene IDBG-23309.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DTX2
Gene Name deltex homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000091073
Encoded Proteins
Protein deltex-2
Protein deltex-2
Protein deltex-2
Protein deltex-2
Protein deltex-2
Protein deltex-2
Protein deltex-2
Protein deltex-2
Protein deltex-2
Protein deltex-2
Protein deltex-2
Protein deltex-2
Protein deltex-2
Protein deltex-2
Protein deltex-2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:76461676-76505995
Strand Forward strand
Band q11.23
Transcripts
ENST00000324432 ENSP00000322885
ENST00000430490 ENSP00000411986
ENST00000413936 ENSP00000390218
ENST00000425780 ENSP00000407398
ENST00000451769 ENSP00000389231
ENST00000456590 ENSP00000409040
ENST00000446600 ENSP00000397648
ENST00000457529 ENSP00000390881
ENST00000423646 ENSP00000415838
ENST00000438930 ENSP00000387894
ENST00000442516 ENSP00000392114
ENST00000429179 ENSP00000403342
ENST00000435861 ENSP00000399639
ENST00000446820 ENSP00000392545
ENST00000435251 ENSP00000410892
ENST00000492339
ENST00000472426
ENST00000467729
ENST00000479915
ENST00000468546
ENST00000465488
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0007219 Notch signaling pathway
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Signaling by NOTCH1 in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Disease pathway
KEGG
Notch signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.187058
RefSeq NM_001102594 NM_001102595 NM_001102596 NM_020892 XM_005250132 XM_005250134 XM_006715846
HUGO
OMIM
CCDS CCDS43605 CCDS5587
HPRD 16841
IMGT
EMBL
GenPept
RNA Seq Atlas