Version 5.4
Homo sapiens Gene: STARD13
Summary
InnateDB Gene IDBG-23340.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STARD13
Gene Name StAR-related lipid transfer (START) domain containing 13
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000133121
Encoded Proteins
IDBP-23342
StAR-related lipid transfer (START) domain containing 13
IDBP-23346
StAR-related lipid transfer (START) domain containing 13
IDBP-230820
StAR-related lipid transfer (START) domain containing 13
IDBP-704270
IDBP-704282
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:33103135-33350630
Strand Reverse strand
Band q13.1
Transcripts
ENST00000336934 ENSP00000338785
ENST00000255486 ENSP00000255486
ENST00000399365 ENSP00000382300
ENST00000439831 ENSP00000457840
ENST00000491333
ENST00000487412
ENST00000498019
ENST00000567873 ENSP00000456233
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 24 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005811 lipid particle
GO:0005829 cytosol
GO:0031966 mitochondrial membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016128
View Gene Order
ENSBTAG00000021815
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.507704 Hs.560163
RefSeq NM_001243476 NM_052851 NM_178006 NM_178007 XM_005266586 XM_006719888 XM_006719889
HUGO
OMIM
CCDS CCDS9348 CCDS9349 CCDS9350
HPRD 11607
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca